Pathologic mechanism of ferric chloride-induced pulmonary fibrosis

Ferric Chloride Induced Dehydrodimerization of Tetrahydrocarbazole

Ferric chloride induced dehydrodimerization of l,2 ,3 ,4 -te trah yd ro-9 //-carb azole (1) gives pro­ duct 6 , the structure of which was established on the basis of its spectroscopic properties. The *H and 13C chemical shifts of the arom atic part of 1 , as well as of 4a-m eth yl-2 ,3 ,4 ,4a-tetrah yd ro-l Hcarbazole (7 a ) and 4a-ph enyl-2 ,3 ,4 ,4a-tetrahyd ro-l//-carb azole (7b ) have also...

Saffron Protection against Bleomycin-Induced Pulmonary Fibrosis in Rats

Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in rats. The aim of this study was to evaluate the effects of saffron aqueous extract on this disorder paving the way for more investigation in treating idiopathic pulmonary fibrosis in human.  Methods: Male Wistar rats (250–300 gr) were instilled a single dose of bleomycin (5 mg/kg) via in...

Rat model of arterial thrombosis induced by ferric chloride.

The purposes of these studies were to produce a small animal model of arterial thrombosis for study of novel antithrombotic agents, to validate a simple temperature index of occlusive thrombosis, and to describe the composition of the thrombus. Small thermocouple transducers were fabricated from readily available materials. A thermocouple was inserted under a carotid artery of the anesthetized ...

Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification.

Background Pathologic Classification of Idiopathic Pulmonary Fibrosis UIP DIP/Respiratory Bronchiolitis Interstitial Lung Disease (RBILD) AIP NSIP Clinical Features of the Idiopathic Interstitial Pneumonias UIP DIP/RBILD AIP N SIP Grading of “Cellularity” and Fibrosis Relationship of UIP and DIP Relationship of AIP and UIP Significance of NSIP—A Specific Disease or a Histologic Manifestation of...

Primary Interstitial Pulmonary Fibrosis: Clinico-pathologic Aspects of the Disease.